The effect of Cinnamaldehyde on changes in the expression of C-jun, C-fos, P53 genes in cancer cells of wistar rat’s gastric tissue by dimethylhydrazine

Azadmanesh, Mahdi; Naji, Tahereh; Mohammadnia, Abdolreza

doi:10.30495/rkctc.2021.19186

Document Type : Original Article

Authors

¹ Department of Basic Sciences School of Pharmacy and Pharmaceutical Sciences, Tehran University of Medical Sciences, Islamic Azad University, Tehran, Iran

² Department of Basic Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Tehran University of Medical Sciences, Islamic Azad University, Tehran, Iran

³ Chronic Respiratory Diseases Research Center, Tuberculosis and Pulmonary Diseases Research Institute, Tuberculosis and Pulmonary Diseases Research Center, Masih Daneshvari Hospital Shahid Beheshti University of Medical Sciences, Tehran, Iran.

10.30495/rkctc.2021.19186

Abstract

Introduction and aim: Genes play a very important role in the development of cancer. This study aimed to evaluate three very important genes (C-fos, C-jun, and P53) in Wistar mice's stomach tissue cancer cells designed by dimethylhydrazine.
Methods: In this study, forty male Wistar mice, 57 weeks old, were evaluated and divided into four groups of Ten. In the control group, the second group received Cinnamaldehyde-free carcinogens, the third group was healthy with the Cinnamaldehyde, and the fourth group received carcinogens with the Cinnamaldehyde at the same time. Then, the gastric tissue of mice was isolated and evaluated for the expression of C-fos, C-Jun, and P53 genes. The data were analyzed with One-way ANOVA using SPSS.
Results: Statistical analysis of the results showed that the expression of C-fos, C-Jun, and P53 genes in the carcinogen receptor with the Cinnamaldehyde was increased compared to the control group. This increase was statistically significant for two genes C-fos (P = 0.0146) and P53 (P = 0.0212) and for the C-Jun gene (P = 0.01604) this increase was not significant.
Conclusion: The results of this study showed that Cinnamaldehyde can alter the expression of important genes C-fos, C-Jun, and P53 that are effective in causing gastric cancer.

Keywords

Main Subjects

Cancer tissue and cell culture

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Research in Cell and Tissue

The effect of Cinnamaldehyde on changes in the expression of C-jun, C-fos, P53 genes in cancer cells of wistar rat’s gastric tissue by dimethylhydrazine

References

References

Volume 2, Issue 3
December 2021
Pages 18-25

The effect of Cinnamaldehyde on changes in the expression of C-jun, C-fos, P53 genes in cancer cells of wistar rat’s gastric tissue by dimethylhydrazine

References

References

Volume 2, Issue 3December 2021Pages 18-25

Volume 2, Issue 3
December 2021
Pages 18-25