Document Type : Original Article


Department of Biology, Faculty of Basic Sciences, Islamic Azad University, Shahrekord Branch, Shahrekord, Iran



Introduction and aim: Hydatid cyst surgery is the most effective treatment. Hydatid cyst recurrence after surgery and the lack of effective and safe Askvlysydl is one of the most important research topics in the treatment of hydatid cysts, which have negative effects on human organs. This study aimed to conduct a full investigation on the impact of the different stages of the parasite herbs and ingredients, to treat helminth infections will significantly contribute to a significant reduction in helminth infections.
Methods: In the present study, the liver of sheep infected with hydatid cyst collected from the slaughterhouse was isolated and the fluid of cysts containing live protoscolices was aspirated under sterile conditions.
Results: After examining the viability protoscolex 1% eosin staining, protoscolex activities Plumbing chamomile extract diluted concentrations of 5%, 2.50%, 1.25%, 0.66%, 0.33% and in time of 0, 10, 20, 30, 40, 50, 60, 120, h24, h72 were studied. 0/5 chamomile extract concentration in the first two hours protoscolex of hydatid cyst can be destroyed. The protoscolices lowest percentage was in the concentration of 0.33% percent in an hour. Dilution of engineering activity increased protoscolex Decreases.
Conclusion: In addition to being affordable chamomile extract, in a short time leads to protoscolex within the hydatid cyst. Scolexes property in dilution laying downtime is less effective.


Main Subjects

Akkari, H., Hajaji, S., B’chir, F., Rekik, M. and Gharbi, M. 2016. Correlation of polyphenolic content with radical-scavenging capacity and anthelmintic effects of rubus ulmifolius (rosaceae) against haemonchus contortus. Veterinary Parasitology, 221: 46-53.
Altintas, N. 2003. Past to present: Echinococcosis in turkey. Acta tropica, 85(2): 105-112.
Arruda, D.C., Miguel, D.C., Yokoyama-Yasunaka, J.K., Katzin, A.M. and Uliana, S.R. 2009. Inhibitory activity of limonene against leishmania parasites in vitro and in vivo. Biomedicine & Pharmacotherapy, 63(9): 643-649.
Budke, C.M., Deplazes, P. and Torgerson, P.R. 2006. Global socioeconomic impact of cystic echinococcosis. Emerging infectious diseases, 12(2): 296.
Buttenschoen, K. and Carli Buttenschoen, D. 2003. Echinococcus granulosus infection: The challenge of surgical treatment. Langenbeck's archives of surgery, 388(4): 218-230.
Cavalieri, E., Mariotto, S., Fabrizi, C., de Prati, A.C., Gottardo, R., Leone, S., Berra, L.V., Lauro, G.M., Ciampa, A.R. and Suzuki, H. 2004. Α-bisabolol, a nontoxic natural compound, strongly induces apoptosis in glioma cells. Biochemical and biophysical research communications, 315(3): 589-594.
Chandrashekhar, V., Ranpariya, V., Ganapaty, S., Parashar, A. and Muchandi, A. 2010. Neuroprotective activity of matricaria recutita linn against global model of ischemia in rats. Journal of ethnopharmacology, 127(3): 645-651.
Dabirzadeh, M., Marofi, Y. and Sefidgar, S.A.A. 2017. Effects of methanolic extract of ficus carica leaves on cystic echinococcosis. Medical Laboratory Journal, 11(3): 15-19.
Dawson, J., Stamatakis, J., Stringer, M. and Williams, R. 1988. Surgical treatment of hepatic hydatid disease. British journal of surgery, 75(10): 946-950.
Dziri, C., Haouet, K. and Fingerhut, A. 2004. Treatment of hydatid cyst of the liver: Where is the evidence? World journal of surgery, 28(8): 731-736.
Eskandarian, A.A. and Shanaz, M. 2008. He therapeutic effect of plant extracts nuts pumpkin and garlic on protoscolex of hydatid cyst. Iranian Scientific Society of Parasitology, pp: 7-9.
Golfam, F., Golfam, P., Khalaj, A., Sayed Mortaz, S. and Taheri, H. 2008. Evolution in treatment methods of hepatic hydatid cyst. Hakim Research Journal, 11(3): 20-26.
Hekmat, A. and Saboury, A.A. 2022. Protein kinase inhibitors and cancer targeted therapy. In: Protein kinase inhibitors (from discovery to therapeutics), I. Hassan and Noor, S., (Eds.). Academic Press.
Izadi, Z., MODARES, S.S., Sorooshzadeh, A., ESNA, A.M. and Davoodi, P. 2013. Antimicrobial activity of chamomile (matricaria chamomilla l.) and feverfew (tanacetum parthenium l.).
Jung, Y.Y., Hwang, S.T., Sethi, G., Fan, L., Arfuso, F. and Ahn, K.S. 2018. Potential anti-inflammatory and anti-cancer properties of farnesol. Molecules, 23(11): 2827.
Kabak, B. and Dobson, A.D. 2017. Mycotoxins in spices and herbs–an update. Critical reviews in food science and nutrition, 57(1): 18-34.
Khan, R. and Sultana, S. 2011. Farnesol attenuates 1, 2-dimethylhydrazine induced oxidative stress, inflammation and apoptotic responses in the colon of wistar rats. Chemico-Biological Interactions, 192(3): 193-200.
Khanfar, N. 2004. Hydatid disease: A review and update. Current Anaesthesia & Critical Care, 15(3): 173-183.
Khodadadi, M., Peyghan, R. and Hamidavi, A. 2013. The evaluation of garlic powder feed additive and its effect on growth rate of common carp, cyprinus carpio. Iranian Journal of Veterinary and Animal Sciences, 6(2): 17-26.
Kumar, A. and Chattopadhyay, T. 1992. Management of hydatid disease of the liver. Postgraduate medical journal, 68(805): 853.
Lee, J.H., Kim, C., Kim, S.-H., Sethi, G. and Ahn, K.S. 2015. Farnesol inhibits tumor growth and enhances the anticancer effects of bortezomib in multiple myeloma xenograft mouse model through the modulation of stat3 signaling pathway. Cancer letters, 360(2): 280-293.
Lorek, J., Pöggeler, S., Weide, M.R., Breves, R. and Bockmühl, D.P. 2008. Influence of farnesol on the morphogenesis of aspergillus niger. Journal of basic microbiology, 48(2): 99-103.
Lygidakis, N.J. 1983. Diagnosis and treatment of intrabiliary rupture of hydatid cyst of the liver. Archives of Surgery, 118(10): 1186-1189.
Murata, Y., Kokuryo, T., Yokoyama, Y., Yamaguchi, J., Miwa, T., Shibuya, M., Yamamoto, Y. and Nagino, M. 2017. The anticancer effects of novel α-bisabolol derivatives against pancreatic cancer. Anticancer Research, 37(2): 589-598.
Pasand, L.H. An epidemiological study on the status of hydatid cyst in surgical patients in golestan hospital of ahwaz during 2002-2011.
Pasand, L.H. 2019. An epidemiological study on the status of hydatid cyst in surgical patients in golestan hospital of ahwaz during 2002-2011.
Rahimi, S. 2014. Evaluation of antibacterial effects of falcaria vulgaris extract on standard strains of staphylococcus aureus and escherichia coli. Razi University. Kermanshah.
Rigo, A. and Vinante, F. 2016. The antineoplastic agent α-bisabolol promotes cell death by inducing pores in mitochondria and lysosomes. Apoptosis, 21(8): 917-927.
Sadraei, H., Sajjadi, S.E., Asghari, G. and Khalili, M. 2019. Effect of matricaria chamomilla hydro-alcoholic and flavonoids rich extracts on rat isolated uterus. Journal of Herbmed Pharmacology, 9(1): 35-41.
Sebai, H., Jabri, M.-A., Souli, A., Rtibi, K., Selmi, S., Tebourbi, O., El-Benna, J. and Sakly, M. 2014. Antidiarrheal and antioxidant activities of chamomile (matricaria recutita l.) decoction extract in rats. Journal of ethnopharmacology, 152(2): 327-332.
Shoorei, H., Khaki, A., Ainehchi, N., Taheri, M.M.H., Tahmasebi, M., Seyedghiasi, G., Ghoreishi, Z., Shokoohi, M., Khaki, A.A. and Raza, S.H.A. 2018. Effects of matricaria chamomilla extract on growth and maturation of isolated mouse ovarian follicles in a three-dimensional culture system. Chinese Medical Journal, 131(02): 218-225.
Youssefi, M.R., Nikpay, A., Hassanpour, N., Mirzapour, A., Tabari, P.S., Pavela, R., Maggi, F. and Petrelli, R. 2020. In vitro scolicidal activity of the sesquiterpenes isofuranodiene, α-bisabolol and farnesol on echinococcus granulosus protoscoleces. Molecules, 25(16): 3593.