نوع مقاله : مقاله پژوهشی

نویسندگان

1 گروه زیست شناسی، دانشکده علوم پایه، واحد علوم و تحقیقات، دانشگاه آزاد اسلامی، تهران، ایران

2 گروه پاتوبیولوژی، واحد علوم و تحقیقات، دانشگاه آزاد اسلامی، تهران، ایران

3 گروه مهندسی بهداشت محیط دانشکده بهداشت و ایمنی عمومی دانشگاه علوم پزشکی شهید بهشتی تهران ایران

10.30495/rkctc.2023.75973.1056

چکیده

مقدمه و هدف: در این مطالعه به بررسی نقش آلاینده­های گازی ( PM2.5) بر تغییرات برخی از شاخص­های خونی و فاکتورهای التهابی بافتی در موش صحرائی در دورهء تیماری شش ماه پرداخته شد.
روش کار: 24 سر موش صحرائی نژاد ویستار به صورت تصادفی در 3 گروه دریافت کنندهء PM2.5 + آلاینده­های گازی (6 ماهه)، دریافت کنندهء آلاینده­های گازی (6 ماهه) و کنترل دریافت کننده­ء هوای تمیز (6 ماهه) تقسیم شدند و برخی شاخص­های خونی و بافتی التهابی مورد ارزیابی قرارگرفتند.
نتایج: نتایج بدست آمده نشان داد که PM2.5 + آلاینده های گازی سبب افزایش اینترلوکین 6 و فاکتور نکروز­کننده آلفا بافتی و کاهش اینترلوکین 10 بافتی در دوره  6 ماهه نسبت به گروه کنترل می­شود. گروه­های تیمار شده با PM2.5 + آلاینده­های گازی نسبت به گروه کنترل، کاهش معنی­داری در میزان گلبول قرمز، گلبول سفید، هموگلوبین و پلاکت نشان دادند.
نتیجه‌گیری: آلودگی هوا به­عنوان یکی از مهمترین دلایل بیماری و مرگ و میر در سراسر جهان می­تواند سبب تغییر در شاخص­های خونی و سلول­های خونی و تغییر برخی از سیتوکین­ها مانند اینترلوکین 6، 10 و فاکتور نکروز­کننده آلفا در بافت ریه شود که ممکن است این سیتوکاین­های التهابی سبب بوجود آمدن رادیکال­های آزاد و اثرات مخرب آن­ها در ریه شود.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

The role of PM2.5 pollution on changes in blood and inflammatory indices in rat lung tissue

نویسندگان [English]

  • mahdi farhadi mahalli 1
  • pejman mortazavi 2
  • Saeed Motesaddi Zarandi 3
  • akram eidi 1

1 Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran

2 Department of Pathobiology, Science and Research Branch, Islamic Azad University, Tehran, Iran.

3 Department of Environmental Health Engineering, School of Public Health and safety, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

چکیده [English]

Introduction and aim: In this study, we have investigated the role of gaseous pollutants and PM2.5 on changes in some blood parameters and inflammatory tissue factors in a rat model in treatment period of six months.
Methods: A total of 24 Wistar rats were randomly divided into 3 groups: receiving PM2.5 + gaseous pollutants (6 months), gaseous pollutants (6 months) and clean air intake control (6 months).
Results: The results showed that the groups treated with PM2.5 + gaseous pollutants showed a significant reduction in the RBC, WBC, HB and PLT count compared to the control group. The results also showed that the level of both interleukin 6 and TNF-α in lung tissue and interleukin 10 were significantly increased and decreased in the PM2.5 + gaseous pollutant group at 6-month period compared to the control group, respectively.
Conclusion: Air pollution PM2.5 as one of the most important causes of disease and mortality worldwide can cause changes in blood parameters such as blood cells and change (increase or decrease) and some cytokines such as interleukin 6, 10 and TNF- α in lung tissue. These inflammatory cytokines may cause the formation of free radicals and their destructive effects in the lung.

کلیدواژه‌ها [English]

  • Air pollution
  • PM2.5
  • Inflammatory cytokines
  • Blood indicators
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