Document Type : Original Article


Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran



Introduction and aim: Palm oil (PO) is the second largest vegetable oil in the world and contains large quantities of phytochemicals, for example, vitamin E, carotenoids, and phytosterols. This study aimed to investigate the effect of Palm oil on the cellular growth of K652 blood cancer, as a model of cancer cells.
Methods: In this study, K562 leukemia cells were treated with concentrations of 5, 25, 50, 75, and 100 µg per mL of PO for 24 and 48 hours. MTT assay, NAC assay, and microscopic observations were used to evaluate cell changes and cell death/survival.
Results: PO at concentrations above 5 μg per ml induced significant cell death. Microscopic observations also confirmed cell death in cells that were treated with PO. Also, the rate of inhibition of cell growth of PO after 24 hours was more than 48 hours. After NAC treatment, 81% cell survival was observed (P <0.001).
Conclusion: According to the results of this study, PO has a great inhibitory effect on K562 leukemia cells and could be a good candidate for cancer therapy.

Main Subjects

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