Original Article Cancer tissue and cell culture
The effect of tamoxifen nanocapsules on the expression of Bax and Bak genes in MCF-7 cell line

Maryam Bikhof Torbati; Masoud Shaabanzadeh; Mahzad Motallebi

Volume 1, Issue 3 , March 2021, Pages 1-7

  Introduction and Aim: Drug nanocarriers have been used extensively in cancer therapy due to their features like the ability to targeting drug transmission, increasing drug solubility, and reducing the drug cytotoxic effects on healthy tissues. The purpose of this study was to investigate the effects ...  Read More

Original Article Cancer tissue and cell culture
Evaluation effects of silymarin on cytotoxicity and apoptosis on SW480 colon cancer cell line

Zainab Kamrani; Masoumeh Heshmati; Sadegh Babashah

Volume 1, Issue 3 , March 2021, Pages 8-15

  Introduction and Aim: Silymarin, extracted from the milk thistle, is rich in flavolignans such as silybinin, silidianin, and silycristine. Several studies have been done on its anticancer effect. This study aimed to evaluate the effects of cytotoxicity and induction of silymarin-induced apoptosis on ...  Read More

Original Article Medical Genetics
Anti-proliferative effect of sodium butyrate against Caco-2 cell line of human colorectal cancer by reducing the expression ratio of BcL-2 to Bax mRNA

Flora Forouzesh; Pantea Hajimirza Shafiesoltani; Mahsa Ghiaghi; Mahdi Shabani

Volume 1, Issue 3 , March 2021, Pages 16-24

  Introduction and Aim: Colorectal cancer is one of the most common cancers. Epigenetic change has been considered by many scientists as a therapeutic target. Hyper acetylation of chromatin components by sodium butyrate can alter gene regulation. This study aims to investigate the effects of sodium butyrate ...  Read More

Original Article Animal cell and culture
Effect of fourth generation of mobile phone standards (4G) on spermatogenesis and testis tissue of NMRI rats

Kazem Parivar; Shahin Shakiba; Azadeh Hekmat

Volume 1, Issue 3 , March 2021, Pages 25-32

  Introduction and Aim: Widespread consumption of cell phones is the most crucial risk factor f human health in the age of technology. This study aimed to explore the effects of 4G mobile phone radiation on the level of spermatogenesis in male rats in 30 days. Methods: In this laboratory experimental study, ...  Read More

Original Article Medical Genetics
Design and Evaluation of real-time PCR for Molecular Diagnosis of Hepatitis B

Hybert keshishian; Shadi Habibnia; Mohamad Reza Fallahian; Saeed Zaker Bostanabad

Volume 1, Issue 3 , March 2021, Pages 33-39

  Introduction and aim: The hepatitis B virus (HBV) was discovered in 1965. Approximately 350 million people are infected with HBV. The virus has a worldwide spread and one of the most important complications of infection is chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Hepatitis can be detected ...  Read More

Original Article Allergy and Algal culture media
An improved method for diatom sample preparation

Ali Naseri; Mostafa Noroozi

Volume 1, Issue 3 , March 2021, Pages 40-45

  Introduction and aim: Diatoms are small phototrophic organisms with an essential role in the food chain in terrestrial and aquatic environments. The purpose of the present study was to optimize and improve the methods for diatom sample preparations. Methods: The difference between the improved method ...  Read More